![]() ![]() The definition of pure dead space is ventilation without perfusion, whereby alveolar gases do not contact blood flowing through the pulmonary capillaries. 2 Physiologic dead-space fraction (dead space divided by tidal volume ), as defined by Bohr and Enghoff, is the sum of anatomic or airway dead space (V D-anat) and alveolar dead space (V D-alv) divided by the V T. Sum Effect….Dead-space ventilation, the portion of a tidal volume that does not contribute to gas exchange, was first described and calculated by the Bohr equation in 1891, 1 and later by the Enghoff modification of the Bohr equation in 1938.improves oxygenation but does not improve outcome.no systemic effects due to rapid inactivation by binding to hemoglobin.vasodilate blood vessels that supply ventilated alveoli and thus improve V/Q.vasodilator with very short half life that can be delivered via ETT.not everyone maintains their response or even responds in the first place.care of patient (suctioning, lines, decubiti) trickier but not impossible.net result is usually improved oxygenation.chest wall has more favorable compliance curve in prone position.re-expand collapsed dorsal areas of the lung.Patient will need to be deeply sedated and perhaps paralyzed as wellĪdvanced Modes High Frequency Oscillatory Ventilation.Can increase MAP without increasing PIP: improve oxygenation but limit barotrauma.central hypoventilation/ frequent apnea.chronic respiratory insufficiency with FTT.MECHANICAL VENTILATION Cori Daines, MD Pediatric Pulmonary Medicine University of Arizona ![]()
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